Publications 

 

2023

  1. Lam SSN, Shi Z, Ip CKM, Wong CKC, and Wong AS (2023) Environmental-relevant bisphenol A exposure promotes ovarian cancer stemness by regulating microRNA biogenesis. J. Cell. Mol. Med. Advance online publication. Full article

  2. Leung CT, Yang Y, Chan TF, Lin X, Wong AS, Lui WY, Yuen KW, Kong RY, Lai KP, and Wu RS(2023) Chromatin modifiers: A new class of pollutants with potential epigenetic effects revealed by in vitro assays and transcriptomic analyses. Toxicology, 484: 153413. Full article

2022

  1. Zhang M, Shi Z, Zhang S, Li X, To SK, Peng Y, Liu J, Chen S, Hu H, Wong AS, Zeng JZ. (2022) The ginsenoside compound K suppresses stem-cell-like properties and colorectal cancer metastasis by targeting hypoxia-driven Nur77-Akt feed-forward signaling. Cancers (Basel). 15(1): 24. Full article

  2. Li X, Chen Q, Liu J, Lai S, Zhang M, Zhen T, Hu H, Gao X, Wong AS, Zeng JZ. (2022) Orphan nuclear receptor Nur77 mediates the lethal endoplasmic reticulum stress and therapeutic efficacy of cryptomeridiol in hepatocellular carcinoma. Cells. 11: 3870. Full article

  3. Xiong Y, Ke R, Zhang Q, Lan W, Yuan W, Chan KNI, Roussel T, Jiang Y, Wu J, Liu S, Wong AS, Shim JS, Zhang X, Xie R, Dusetti N, Iovanna J, Habib N, Peng L, and Lee LTO (2022) Small activating RNA modulation of the G protein-coupled receptor for cancer treatment. Adv. Sci. e2200562. Full article

  4. To SK, Tang KS, Tong Y, Zhang J, Chan KK, Ip PP, Shi J, and Wong AS* (2022) A selective b-catenin-metadherin/CEACAM1-CCL3 axis mediates metastatic heterogeneity upon tumor-macrophage interaction. Adv. Sci. e2103230. Full article

  5. Artemenko M, Zhong SS, To SK, and Wong AS* (2022) p70 S6 kinase as a therapeutic target in cancers: more than just an mTOR effector. Cancer Lett. 535: 215593. Full article

  6. Hassan AA, Artemenko M, Tang MK, Shi Z, Chen LY, Lai HC, Yang Z, Shum HC, and Wong AS* (2022) Ascitic fluid shear stress in concert with hepatocyte growth factor drive stemness and chemoresistance in ovarian cancer cells via the miR-199a-3pd signaling pathway. Cell Death Dis. 13: 537. Full article

  7. Tsang SI, Hassan AA, To SK, and Wong AS* (2022) Experimental models for ovarian cancer research. Exp. Cell Res. 113150. Full article

2021

  1. Yi C, Lai SK, Tsang CM, Artemenko M, Tang MK, Pang SW, Lo KW, Tsao SW, and Wong AS* (2021) A 3D spheroid-specific role of Wnt/b-catenin and Eph/Ephrin in nasopharyngeal carcinoma cells. J. Cell Sci. 134: jcs256461. Full article

  2. Leung CT, Yang Y, Yu PK, Tam N, Chan TF, Lin X, Kong YC, Chiu JM, Wong AS, Lui WY, Yuen KW, Lai KP, and Wu RS (2021) Low-dose radiation can cause epigenetic alterations associated with impairments in both male and female reproductive cells. Front. Genet. 12: 710143. Full article

  3. Wan PK, Tong KC, Lok CN, Zhang C, Chang XY, Sze KH, Wong AS, Che CM. Platinum(II) N-heterocyclic carbene complexes arrest metastatic tumor growth. Proc. Natl. Acad. Sci. U. S. A. 118:e2025806118. Full article

  4. Han Q, Xie QR, Li F, Cheng Y, Wu T, Zhang Y, Lu X, Wong AS, Sha J, and Xia W (2021) Targeted inhibition of SIRT6 via engineered exosomes impairs tumorigenesis and metastasis in prostate cancer. Theranostics 11: 6526-6541. Full article

  5. Shi Z, To SKY, Zhang S, Deng S, Artemenko M, Zhang M, Tang J, Zeng JZ, Wong AS*. Hypoxia-induced Nur77 activates PI3K/Akt signaling via suppression of Dicer/let-7i-5p to induce epithelial-to-mesenchymal transition. Theranostics 11:3376-3391. Full article

2020

  1. Zhang Q, Zhou W, Yu S, Ju Y, To SKY, Wong AS, Jiao Y, Poon TCW, Tam KY, Lee LTO. Metabolic reprogramming of ovarian cancer involves ACSL1-mediated metastasis stimulation through upregulated protein myristoylation. Oncogene 40: 97-111. Full article

  2. Hassan AA, Artemenko M, Tang MKS, Wong AS. Selectins: An Important Family of Glycan-Binding Cell Adhesion Molecules in Ovarian Cancer. Cancers (Basel) 12:2238. Full article

  3. Shen FF, Dai SY, Wong NK, Deng S, Wong AS, and Yang D. Mediating K+/H+ Transport on Organelle Membranes to Selectively Eradicate Cancer Stem Cells with a Small Molecule. J. Am. Chem. Soc. 142:10769-10779. Abstract

  4. Kan T, Wang W, Ip PP, Zhou S, Wong AS, Wang X, and Yang M. Single-cell EMT-related transcriptional analysis revealed intra-cluster heterogeneity of tumor cell clusters in epithelial ovarian cancer ascites. Oncogene 39: 4227–4240. Full article

  5. Yu Y, Tse KY, Lee H, Chow KL, Tsang HW, Wong R, Cheung E, Cheuk W, Lee V, Chan WK, Wong AS, Loong H, Chan K, Ngan H, Cheung A, and Ip P. (2020). Predictive biomarkers and tumor microenvironment in female genital melanomas: a multi-institutional study of 55 cases. Mod. Pathol. 33:138-152. Abstract

  6. Wong AS, Wong CKC. Ginsenoside-Rb1 as an anti-cancer therapeutic: abridged secondary publication. Hong Kong Med J. 26 Suppl 8:16-17. Abstract

2019

  1. Shi ZY, Zeng JZ, and Wong AS.* Chemical Structures and Pharmacological Profiles of Ginseng Saponins. Molecules (Basel, Switzerland) 24: 2443. Full article

  2. Li SS, Ip CK, Tang MY, Tang MK, Tong Y, Zhang J, Hassan AA, Mak AS, Yung S, Chan TM, Ip PP, Lee CL, Chiu PC, Lee LT, Lai HC, Zeng JZ, Shum HC, and Wong AS*. Sialyl lewisx-P-selectin cascade mediates tumor-mesothelial adhesion in ascitic fluid shear flow. Nat. Commun 10: 2406. Full article

  3. Zhang Q, Yu S, Lok SI, Wong AS, Jiao Y, and Lee LT. FAM83D promotes ovarian cancer progression and its potential application in diagnosis of invasive ovarian cancer. J. Cell. Mol. Med. 23: 4569-4581.Abstract

  4. Lai KP, Wang Y, Li JW, Tong Y, Chan TF, Jin N, Tse A, Zhang J, Wan MT, Tam N, Au DW, Lee BY, Lee JS, Wong AS, Kong RY, and Wu RS. Hypoxia causes transcriptional impairment of ovarian development in fish. Environ. Sci. Tech. 53: 3917-3928. Abstract

  5. Zhang Q, Yu S, Lam MM, Poon TC, Sun L, Jiao Y, Wong AS, and Lee LT. Angiotensin II promotes ovarian cancer spheroid formation and metastasis by upregulation of lipid desaturation and suppression of endoplasmic reticulum stress. J. Exp. Clin. Cancer Res. 38: 116. Abstract

2018

  1. Yuan H, Chao Y, Li SS, Tang M, Huang Y, Che Y, Wong AS, Zhang T, and Shum HC (2018) Picoinjection-enabled multi-target loop-mediated isothermal application (LAMP) for detection of foodborne pathogen. Anal. Chem. 90: 13173-13177. Abstract

  2. Tang MK, Ip PP, and Wong AS* (2018) New insights into the role of soluble E-cadherin in tumor angiogenesis. Cell Stress 2: 236-238. 

  3. Tang MK, Yue PY, Huang RL, Lai HC, Ip PP, Cheung AN, Tse KY, Ngan HY, and Wong AS* Soluble E-cadherin promotes tumor angiogenesis and localizes to exosome surface. Nat. Commun. 9: 2270. Abstract

  4. Li SS, Ma J, and Wong AS* (2018) Chemoresistance in ovarian cancer: exploiting cancer stem cell metabolism. J. Gynecol. Oncol. 29: e32. Abstract

  5. Ma J, Kala, S, Yung S, Chan TM, Cao Y, Liu X, Giorgio S, Peng L, and Wong AS* (2018) Blocking stemness and metastatic properties of ovarian cancer cells by targeting p70S6K with dendrimer nanovector-based siRNA delivery. Mol. Ther. 26: 70-83 (Cover Story). Abstract

2017

  1. To SK, Mak AS, Fung YM, Che CM, Li SS, Deng W, Ru B, Zhang J, and Wong AS* (2017) β-catenin downregulates Dicer to promote ovarian cancer metastasis. Oncogene 36: 5927-5938. Abstract  

  2. Yip KY, Wan ML, Wong AS, Korach KS, and El-Nezami (2017) Combined low dose zearalenone and aflatoxin B1 on cell growth and cell cycle progression in breast cancer MCF-7 cells. Toxicol. Lett. 281: 139-151. Abstract

  3. Neoh KH, Hassan AA, Chen A, Sun Y, Liu P, Xu KF*, Wong AS*, and Han R* (2017) Rethinking liquid biopsy: microfluidic assays of mobile tumor cells in human body fluids. Biomaterials 150: 112-124. Abstract

  4. Tey SK, Tse EY, Mao X, Ko FC, Wong AS, Lo RC, Ng IO, and Yam JW (2017) Nuclear Met promotes hepatocellular carcinoma tumorigenesis and metastasis by upregulation of TAK1 and activation of NF-kB pathway. Cancer Lett. 411: 150-161. Abstract

  5. Liu J, Wang H, Chen G, Yang M, Wu Z, Ericksen RE, Wong AS, Han W, and Zeng JZ (2017) The synergy of helicobacter pylori and lipid metabolic disorders in induction of Th17-related cytokines in human gastric cancer. J. Cancer Metastasis Treat. 3: 169-176.  Abstract

  6. Zhou ZL, Sun XX, Ma J, Tong MH, To SK, Wong AS, and Ngan AH (2017) Actin cytoskeleton stiffness as a biomarker for metastatic potential in ovarian carcinoma cells. J. Biomechan. 60: 219-226. Abstract

  7. Zhou SF, Gopalakrishnan S, Xu YH, To SK, Wong AS, Pang SW, and Lam YW (2017) Substrates with patterned topography reveal invasiveness of human cancer cells. Biomed. Mater. 12: 055001. Abstract

  8. Zhang Q, Madden NE, Wong AS, Chow BK, and Lee LT (2017) The role of endocrine G protein-coupled receptors in ovarian cancer progression. Front. Endocrinol. (Lausanne) 8: 66. Abstract

  9. Zeng W, Zhang C, Cheng H, Wu YL, Liu J, Chen Z, Huang JG, Ericksen RE, Chen L, Zhang H, Wong AS*, Zhang XK, Han W, and Zeng JZ (2017) Targeting to the non-genomic activity of retinoic acid receptor-gamma by acacetin in hepatocellular carcinoma. Sci. Rep. 7: 348. Abstract

  10. Wang P, Zeng W, Liu J, Wu YL, Ma Y, Zeng Z, Pang J, Zhang XK, Yan X, Wong AS, and Zeng JZ (2017) TRC4, an improved triptolide derivative, specifically targets to truncated form of retinoid X receptor-alpha in cancer cells. Biochem. Pharmacol. 124: 19-28. Abstract

  11. Li S, Ip CK, Tang MY, Sy SK, Yung S, Chan TM, Yang M, Shum HC, and Wong AS* (2017) Modeling ovarian cancer multicellular spheroid behaviors in a dynamic 3D peritoneal microdevice. J. Vis. Exp. 120: doi:10.3791/55337. Abstract

  12. Deng S, Wong CK, Lai HC, and Wong AS * (2017) Ginsenoside-Rb1 targets chemotherapy-resistant ovarian cancer stem cells via simultaneous inhibition of Wnt/b-catenin signaling and epithelial-to-mesenchymal transition. Oncotarget 8: 25897-25914. Abstract

2016

  1. Zhou ZL, Ma J, Tong MH, Chan BP, Wong AS, and Ngan AH (2016) Nanomechanics measurement of adhesion and migration of leukemia cells with phorbol 12-myristate 13-acetate treatment. Int. J. Nanomed. 11: 6533-6545. Abstract

  2. Zhang M, Li D, Li M, Wong AS, and Sun RW (2016) Enhanced anti-cancer activities of a gold(III) pyrrolidinedithiocarbamato complex incorporated in a biodegradable metal-organic framework. J. Inorg. Biochem. 163: 1-7. Abstract

  3. Wang SY, Lau K, Lai KP, Zhang JW, Tse AC, Li JW, Tong Y, Chan TF, Wong CK, Chiu JM, Au DW, Wong AS, Kong RY, and Wu RS (2016) Hypoxia causes transgenerational impairments in reproduction of fish. Nat. Commun. 7: 12114. Abstract

  4. Lam SS, Ip CK, Mak AS, and Wong AS* (2016) A novel p70 S6 kinase-microRNA biogenesis axis mediates multicellular spheroid formation in ovarian cancer progression. Oncotarget 7: 38064-30877. Abstract

  5. Ip CK, Li SS, Tang MY, Sy SK, Ren Y, Shum HC, and Wong AS* (2016) Stemness and chemoresistance in epithelial ovarian carcinoma cells under shear stress. Sci. Rep. 6: 26788. Abstract

  6. Zhou ZL, Sun XX, Ma J, Man CH, Wong AS, Leung AY, and Ngan AH (2016) Mechanical oscillations enhance gene delivery into suspending cells. Sci. Rep. 6: 22824. Abstract

2015

  1. Choi R, Wong AS, Jia W, Chang IM, Wong RN, Fan TP, and Kim YS (2015) Panax – a panacea linking East Asia and North America. Science 350 (6262 Suppl): S54-S56. 

  2. Sun RWY, Zhang M, Li D, Zhang ZF, Cai H, Li M, Xian YJ, Ng SW, and Wong AS (2015) Dinuclear gold(I) pyrrolidinedithiocarbamato complex: cytotoxic and antimigratory activities on cancer cells and the use of metal-organic framework. Chemistry 21: 18534-18538. Abstract

  3. Tang MK and Wong AS* (2015) Exosomes: Emerging biomarkers and targets for ovarian cancer. Cancer Lett. 367: 26-33.  Abstract

  4. Wong AS*, Che CM, and Leung KW (2015) Recent advances in ginseng as cancer therapeutics: a functional and mechanistic overview. Nat. Prod. Rep. 32: 256-272.  Abstract

  5. So WK, Cheng JC, Fan Q, Wong AS, Huntsman DG, Gilks B, and Leung PC (2015) Loss of Sprouty2 in human high-grade serous ovarian carcinomas promotes EGF-induced E-cadherin down-regulation and cell invasion. FEBS Lett. 589: 302-309.  Abstract

2014

  1. Ip CK, Yung S, Chan TM, Tsao SW, and Wong AS* (2014) p70 S6 kinase drives ovarian cancer metastasis through multicellular spheroid-peritoneum interaction and P-cadherin/β1 integrin signaling activation. Oncotarget 5: 9133-9149.  Abstract

  2. Kala S, Mak AS, Liu X, Posocco P, Pricl S, Peng L, and Wong AS*. Combination of dendrimer nanovector mediated siRNA delivery to target Akt with clinical anticancer drug paclitaxel for effective and potent anticancer activity in treating ovarian cancer. J. Med. Chem. 57: 2634-2642. Abstract

  3. Lam SS, Mak AS, Yam JW, Cheung AN, Ngan HY, and Wong AS*. Targeting estrogen-related receptor alpha inhibits epithelial to mesenchymal transition and stem cell properties of ovarian cancer cells. Mol. Ther. 22: 743-751. Abstract

  4. Tang MK, Kwong A, Tam KF, Cheung AN, Ngan HY, Xia W, and Wong AS* (2014) BRCA1 deficiency induces protective autophagy to mitigate stress and provides a mechanism for BRCA1 haploinsufficiency in tumorigenesis. Cancer Lett. 346: 139-147. Abstract

  5. To SK, Zeng WJ, Zeng JZ, and Wong AS* (2014) Hypoxia triggers a Nur77-β-catenin feed-forward loop to promote the invasive growth of colon cancer cells. Br J. Cancer 110: 935-945. Abstract

2013

  1. Cheung LW, Yung S, Chan TM, Leung PC, and Wong AS* (2013) Targeting gonadotropin-releasing hormone receptor inhibits the early step of ovarian cancer metastasis by modulating tumor-mesothelial adhesion. Mol. Ther. 21: 78-90. Abstract

  2. Chau WK, Ip CK, Mak AS, Lai HC, and Wong AS*. c-Kit mediates chemoresistance and tumor-initiating capacity of ovarian cancer cells through activation of Wnt/β-catenin-ATP-binding cassette G2 signaling.Oncogene 32: 2767-2781. Abstract

  3. Lum CT, Wong AS, Lin MC, Tong KK, Che CM, and Sun RW. Gold(III) porphyrin complex as an anti-cancer candidate to inhibit the growth of cancer-stem cells. Chem Comm 49: 4364-4366. Abstract

2012

  1. Ip CK and Wong AS* (2012) Exploiting p70 S6 kinase as a target for ovarian cancer. Expert Opin. Ther. Targets 16: 619-630. Abstract

  2. To SK, Zeng JZ, and Wong AS* (2012) Nur77: a potential therapeutic target in cancer. Expert Opin. Ther. Targets 16: 573-585. Abstract

  3. Tse E, Ko FC, Tung EK, Lee TK, Hui L, Ngan ES, Wong AS, Ng IO, and Yam JW (2012) Caveolin-1 overexpression is associated with hepatocellular carcinoma tumorigenesis and metastasis. J. Pathol. 226: 645-653. Abstract

2011

  1. Leung KW, Ng HM, Tang MK, Wong CK, Wong RN, and Wong AS* (2011) Ginsenoside-Rg1 mediates a hypoxia-independent upregulation of hypoxia-inducible factor-1a to promote angiogenesis. Angiogenesis 14: 515-522. Abstract

  2. Leung WK, Ching AK, Chan AW, Poon TC, Mian H, Wong AS, To KF, and Wong N (2011) A novel interplay between oncogenic PFTK1 protein kinase and tumor suppressor TAGLN2 in the control of liver cancer cell motility. Oncogene 30: 4464-4475. Abstract

  3. Cheung LW, Mak AS, Cheung AN, Ngan HY, Leung PC, and Wong AS* (2011) P-cadherin cooperates with insulin-like growth factor-1 receptor to promote metastatic signaling of gonadotropin-releasing hormone in ovarian cancer via p120 catenin. Oncogene 30: 2964-2974. Abstract

  4. Ip CK, Cheung AN, Ngan HY, and Wong AS* (2011) p70 S6 kinase in the control of actin cytoskeleton dynamics and directed migration of ovarian cancer cells. Oncogene 30: 2420-2432.Abstract

  5. Cheung LW, Leung KW, Wong CK, Wong RN, and Wong AS* (2011) Ginsenoside-Rg1 induces angiogenesis via non-genomic cross-talk of glucocorticoid receptor and fibroblast growth factor receptor-1. Cardiovasc. Res. 89: 419-425.  Abstract

  6. Wu H, Lin Y, Li W, Sun Z, Gao W, Zhang H, Xie L, Jiang F, Qin B, Yan T, Chen L, Zhao Y, Cao X, Wu Y, Lin B, Zhou H, Wong AS, Zhang XK, and Zeng JZ (2011) Regulation of Nur77 expression by β-catenin and its mitogenic effect in colon cancer cells. FASEB J. 25: 192-205. Abstract

2010

  1. Leung KW, and Wong AS (2010) Pharmacology of ginsenosides: a literature review. Chin. Med. 5: 20. Abstract

  2. Cheung LW, Leung PC and Wong AS* (2010) Cadherin switching and activation of p120 catenin signaling are mediators of gonadotropin-releasing hormone to promote tumor cell migration and invasion in ovarian cancer. Oncogene 29: 2427-2440. Abstract

  3. Tang MK, Zhou HY, Yam JW and Wong AS* (2010) c-Met overexpression contributes to the acquired apoptotic resistance of ovarian cancer cells through a cross-talk mediated by phosphatidylinositol 3-kinase and extracellular-signal regulated kinase 1/2. Neoplasia 12: 128-138 (Highlighted paper).  Abstract

  4. Wong AS* (2010) An experimental model of ovarian carcinoma – more than just genetics. Cell Cycle 9: 228-229. Abstract

  5. Ting CM, Lee YM, Wong CK, Wong AS, Lung HL, Lung ML, Lo KW, Wong RN, Mak NK (2010) 2-Methoxyestradiol induces endoreduplication through the induction of mitochondrial oxidative stress and the activation of MAPK signaling pathways. Biochem. Pharmacol. 79: 825-841. Abstract

  6. Ching WK, Li L, Tsing NK, Tai CW, Ng TW, Wong AS, and Cheng KW (2010) A weighted local least squares imputation method for missing value estimation in microarray gene expression data. Int. J. Data Min. Bioinform.4, 331-347. Abstract

  7. Lau MT, Wong AS and Leung PC. Gonadotropins induce tumor cell migration and invasion by increasing cyclooxygenases expression and prostaglandin E2 production in human ovarian cancer cells. Endocrinology 151: 2985-2993. Abstract

2009

  1. Ching WK, Zhang SQ, Jiao Y, Akutsu T, Tsing NK and Wong AS (2009) Optimal control policy for probabilistic Boolean networks with hard constraints. IET Systems Biology 3: 90-99. Abstract

2008

  1. Pon YL, Zhou HY, Cheung AN, Ngan HY and Wong AS* (2008) p70 S6 kinase promotes epithelial to mesenchymal transition through Snail induction in ovarian cancer cells. Cancer Res. 68: 6524-6532. Abstract

  2. Yeung BH, Kwan BW, He QY, Lee AS, Liu J and Wong AS* (2008) Glucose-regulated protein 78 as a novel effector of BRCA1 for inhibiting stress-induced apoptosis. Oncogene 27: 6782-6789. Abstract

  3. Yeung BH, Wong KY, Lin MC, Wong CK, Mashima T, Tsuruo T and Wong AS* (2008) Chemosensitization by manganese superoxide dismutase inhibition is caspase-9 dependent and involves extracellular signal-regulated kinase 1/2. Br. J. Cancer 99: 283-293. Abstract

  4. Zhou HY, Pon YL and Wong AS* (2008) HGF/MET signaling in ovarian cancer. Curr. Mol. Med. 8: 469-480. Abstract

  5. Cheung LW and Wong AS* (2008) GnRH receptor signaling in extrapituitary tissues. FEBS J. 275: 5479-5495. Abstract

  6. Zhou HY, Wan KF, Ip CK, Wong CK, Mak NK, Lo KW and Wong AS* (2008) Hepatocyte growth factor enhances proteolysis and invasiveness of human nasopharyngeal cancer cells through activation of PI3K and JNK. FEBS Lett. 582: 3415-3422. Abstract

  7. Law AY, Lai KP, Ip CK, Wong AS, Wagner GF and Wong CK (2008) Epigenetic and HIF-1 regulation of stanniocalcin-2 expression in human cancer cells. Exp. Cell Res. 314: 1823-1830. Abstract

  8. Park SH, Cheung LW, Wong AS and Leung PC (2008) Estrogen regulates Snail and Slug in the downregulation of E-cadherin and induces metastatic potential of ovarian cancer cells through estrogen receptor alpha. Mol. Endocrinol. 22: 2085-2098 (Highlighted paper). Abstract

2007

  1. Cheung LW, Lee YF, Ng TW, Ching WK, Khoo US, Ng MK and Wong AS* (2007) CpG/CpNpG sites in the coding region are preferred sites for mutagenesis in the breast cancer susceptibility genes. FEBS Lett. 581: 4668-4674. Abstract

  2. Zhou HY, Pon YL and Wong AS*(2007) Synergistic effects of epidermal growth factor and hepatocyte growth factor on human ovarian cancer cell invasion and migration: role of ERK1/2 and p38 MAPK. Endocrinology 148: 5195-5208. Abstract

  3. Choi JH, Wong AS, Huang HF and Leung PC (2007) Gonadotropins and ovarian cancer. Endocr. Rev. 28: 440-461. Abstract

  4. Chen CL, Cheung LW, Lau MT, Choi JH, Auersperg N, Wang HS, Wong AS and Leung PC (2007) Differential role of gonadotropin-releasing hormone on human ovarian epithelial cancer cell invasion. Endocrine 31: 311-320.  Abstract

  5.  Leung KW, Cheung LW, Pon YL, Wong RN, Mak NK, Fan TP, Au SC, Tombran-Tink J and Wong AS* (2007) Ginsenoside-Rb1 inhibits angiogenesis by regulating pigment epithelium-derived factor through estrogen receptor beta in human endothelial cells. Br. J. Pharmacol. 152: 207-215 (Special Commentary). Abstract

  6. Wong AS* and Leung PC (2007) Role of endocrine and growth factors on the ovarian surface epithelium. J. Obstet. Gynaecol. Res. 33: 3-16. Abstract

2006

  1. Pon YL and Wong AS* (2006) Gonadotropin-induced apoptosis in human ovarian surface epithelial cells is associated with cyclooxygenase-2 upregulation via the β-catenin/T cell factor signaling pathway. Mol. Endocrinol.20: 3336-3350. Abstract

  2. Leung KW, Pon YL, Wong RN and Wong AS* (2006) Ginsenoside-Rg1 induces vascular endothelial growth factor expression through glucocorticoid receptor-related phosphatidylinositol 3-kinase/Akt and β-catenin/TCF dependent pathway in human endothelial cells.J. Biol. Chem. 281: 36280-36288. Abstract

  3. Cheung LW, Au SC, Cheung AN, Ngan HY, Tombran-Tink J, Auersperg N and Wong AS* (2006) Pigment epithelium-derived factor is estrogen sensitive and inhibits the growth of human ovarian cancer and ovarian surface epithelial cells. Endocrinology 147:4179-4191. Abstract

  4. Cheung LW, Leung PC and Wong AS* (2006) Gonadotropin-releasing hormone promotes ovarian cancer cell invasiveness through c-Jun N-terminal kinase-mediated activation of matrix metalloproteinase-2 and -9. Cancer Res. 66: 10902-10910. Abstract

  5. Zhou HY and Wong AS* (2006) Activation of p70S6K induces expression of matrix metalloproteinase 9 associated with hepatocyte growth factor-mediated invasion in human ovarian cancer cells. Endocrinology 147: 2557-2566. Abstract

2005

  1. He QY, Zhou Y, Wong E, Ehlen TG, Auersperg N, Chiu JF and Wong AS* (2005) Proteomic analysis of a preneoplastic phenotype in ovarian surface epithelial cells derived from prophylactic oophorectomies. Gynecol. Oncol.98: 68-76. Abstract

  2. Pon YL, Auersperg N and Wong AS* (2005) Gonadotropins regulate N-cadherin-mediated human ovarian surface epithelial cell survival at both post-translational and transcriptional levels through a cyclic AMP/protein kinase A pathway. J. Biol. Chem. 280: 15438-15448.  Abstract

2004

  1. Wong AS, Roskelley CD, Pelech S, Miller D, Leung PC and Auersperg N (2004) Progressive changes in Met-dependent signaling in a human ovarian surface epithelial model of malignant transformation. Exp. Cell Res. 299: 248-256 (Highlighted paper). Abstract

  2. Maines-Bandiera SL, Huntsman D, Lestou VS, Kuo W-L, Leung PC, Horsman RD, Wong AS, Woo MMM, Choi KKC, Roskelley CD and Auersperg N (2004) Epithelio-mesenchymal transition in a neoplastic ovarian epithelial hybrid cell line. Differentiation 72: 150-161. (2004). Abstract

2003

  1. Wong AS* and Auersperg N (2003) Ovarian surface epithelium: family history and early events in ovarian cancer. Reprod. Biol. Endocrinol. 1: 70-77. Abstract

  2. Wong AS and Gumbiner BM (2003) Adhesion-independent mechanism for suppression of tumor cell invasion by E-cadherin. J. Cell Biol.161: 1191-1203 (Highlighted paper). Abstract

Before joining HKU

  1. Wong AS, Pelech SL, Woo MM, Yim G, Rosen B, Ehlen T, Leung PC and Auersperg N (2001) Coexpression of hepatocyte growth factor-Met: as an early step in ovarian carcinogenesis? Oncogene 20: 1318-1328. Abstract

  2. Auersperg N, Wong AS, Choi KC, Kang SK and Leung PC (2001) Ovarian surface epithelium: biology, endocrinology, and pathology. Endocr. Rev. 22: 255-288. Abstract

  3. Wong AS, Kim SO, Leung PC, Auersperg N and Pelech SL (2001) Profiling of protein kinases in the neoplastic transformation of human ovarian surface epithelium. Gynecol. Oncol. 82: 305-311. Abstract

  4. Wong AS, Lui WY, Hui IT and Lee WM (2001) Rabbit SHBG: biosynthesis in the liver and testis during postnatal development and structural characterization by truncated proteins. Int. J. Androl. 24: 165-174. Abstract

  5. Wong AS, Leung PC and Auersperg N (2000) Hepatocyte growth factor promotes in vitro scattering and morphogenesis of human cervical carcinoma cells. Gynecol. Oncol. 78: 158-165. Abstract

  6. Wong AS, Maines-Bandiera SL, Roskelley CD, Rosen B, Wheelock MJ, Johnson KR, Leung PC and Auersperg N (1999) Constitutive and conditional cadherin expression in cultured human ovarian surface epithelium: Influence of family histories of ovarian cancer.  Int. J. Cancer 81: 180-188. Abstract

  7. Wong AS, Maines-Bandiera SL, Leung PC and Auersperg N (1998) Metaplastic changes in cultured ovarian surface epithelium. In Vitro Cell. Dev. Biol.34: 668-670 (Cover story). Abstract

  8. Lee WM, Wong AS, Tu AWK, Cheung CH, Li JCH and Hammond GL (1997) Rabbit sex hormone binding globulin: primary structure, tissue expression, and structure/function analyses by expression in E. coli. J. Endocrinol. 153: 373-384. Abstract

Book Chapters

  1. Chan RW, Mak AS, Yeung WS, Lee KF, Cheung AN, Ngan HY, and Wong AS* (2013) Human female reproductive tract epithelial cell culture. Methods Mol. Biol. 945: 347-363.

  2. Wong AS* (2012) Protein kinases. In Encyclopedia of Cancer (3rd Edition), M. Schwab ed., Springer, DOI: 10.1007/SpringerReference_178277.

  3. Cheung LW, Ip CK, and Wong AS* (2010) Chapter 12 Cadherin-catenin signaling in ovarian cancer progression. In: “Signal Transduction in Cancer Metastasis” Cancer Metastasis Biology & Treatment Series, W. S. Wu and C. T. Hu eds., Springer Life Sciences – Biomedical Unit, p.225-253.

  4. Yue PY, Cheng YK, Mak NK, Leung KW, Wong AS, Fan TP, and Wong RN (2007) Chapter 22 Ginseng and angiogenesis. In: Angiogenesis: Basic Science and Clinical Applications, M. E. Maragoudakis and E. Papadimitriou eds., Transworld Research Network Publisher, p.357-372.

  5. Wong AS and Auersperg N (2002) Normal ovarian surface epithelium. Cancer Treat. Res. 107: 161-183.